PT731. A study of clinical factors related to intelligence diminution after onset of mental disorders

Objective: We evaluated the association between prescribed medications and mental status such as sleep, mood, and cognition in Korean elderly. Method: We investigated the number of medications of 604 individuals (281 men and 323 women) who taken prescription without major depressive disorder and dementia. They were enrolled in the Korean Longitudinal Study on Health and Aging (KLoSHA), a community-based cohort of aged ≥65 year. The daily total average number of medications used at least once a month including oral, injections, and external preparations except eye drops was calculated. The Pittsburgh Sleep Quality Index (PSQI), Korean version of the Geriatric Depression Scale (GDS-K), Subjective Memory Complain Questionnaire (SMCQ) were evaluated for subjective mental status. Results: The mean age of men and women was 76.10 ± 8.33 and 75.20 ± 7.86 years. The average number of medications used in men was 6.16 ± 5.98 and in women was 5.53 ± 5.77. The number of medications significantly correlated with PSQI score(r=0.14, 95% confidence interval (CI), 0.14 to 0.26) and GDS score (r=0.13, 95% CI, 0.02 to 0.25) in men but not in women. However it was not significant after adjusting for the illness burden of any comorbid illnesses. Conclusion: In elderly men, an increasing number of prescription medications have a relation to sleep quality and mood, unlike elderly women. PT731 A study of clinical factors related to intelligence diminution after onset of mental disorders Kenichi Oga, Yosuke Fujita, Kei Itagaka, Yoshio Kawashita, Hironori Kobayashai, Hanae Minami, Kenichiro Nishimura, Wataru Omori, Minoru Takebayashi, Saki Tamiya National Hospital Organization Kure Medical Center, Japan Abstract Background: The presence and degree of cognitive function and intelligence diminution is important for diagnosis of mental disorders. The National Adult Reading Test (NART) is widely used as a measure of premorbid IQ of English-speaking patients with mental disorders. The Japanese Adult Reading Test (JART) is Japanese version of NART uses kanji (ideographic script) compound words. In this study, we examined clinical factors related to intelligence diminution after onset of mental disorders using the estimated premorbid IQ by JART and present IQ by WAIS-III. Methods: We retrospectively reviewed the records of 46 patients who have taken JART and WAIS-III. We examined the relation of intelligence diminution after onset and clinical factors such as age, sex, clinical diagnosis, duration of disease and amount of drugs for remitted 29 patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorder and anxiety disorder. Results: In the schizophrenia group including schizophrenia and schizoaffective disorders, the estimated premorbid IQ was 97.8 ± 8.2, and present IQ was 79.3 ± 13.3. In the non-schizophrenia group including bipolar disorder, major depressive disorder and anxiety disorder, the estimated premorbid IQ was 104.9 ± 8.1, and present IQ was 98.0 ± 13.6. Degree of intelligence diminution was significantly larger in the schizophrenia group. Multivariate analysis revealed that only diagnosis (schizophrenia group) was significantly related to intelligence diminution after onset. Conclusion: Degree of intelligence diminution may be an auxiliary useful for diagnosis of schizophrenia. However, this was preliminary study for a small number of patients, and it is necessary to examine a larger number of patients and to look specifically at each disorder.Background: The presence and degree of cognitive function and intelligence diminution is important for diagnosis of mental disorders. The National Adult Reading Test (NART) is widely used as a measure of premorbid IQ of English-speaking patients with mental disorders. The Japanese Adult Reading Test (JART) is Japanese version of NART uses kanji (ideographic script) compound words. In this study, we examined clinical factors related to intelligence diminution after onset of mental disorders using the estimated premorbid IQ by JART and present IQ by WAIS-III. Methods: We retrospectively reviewed the records of 46 patients who have taken JART and WAIS-III. We examined the relation of intelligence diminution after onset and clinical factors such as age, sex, clinical diagnosis, duration of disease and amount of drugs for remitted 29 patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorder and anxiety disorder. Results: In the schizophrenia group including schizophrenia and schizoaffective disorders, the estimated premorbid IQ was 97.8 ± 8.2, and present IQ was 79.3 ± 13.3. In the non-schizophrenia group including bipolar disorder, major depressive disorder and anxiety disorder, the estimated premorbid IQ was 104.9 ± 8.1, and present IQ was 98.0 ± 13.6. Degree of intelligence diminution was significantly larger in the schizophrenia group. Multivariate analysis revealed that only diagnosis (schizophrenia group) was significantly related to intelligence diminution after onset. Conclusion: Degree of intelligence diminution may be an auxiliary useful for diagnosis of schizophrenia. However, this was preliminary study for a small number of patients, and it is necessary to examine a larger number of patients and to look specifically at each disorder. PT732 Successful treatment with a combination of thyrotropin-releasing hormone (TRH) and hyperbaric oxygen (HBO) for an interval form of carbon monoxide (CO) poisoning Waturu Omori, Yosuke Fujita, Kenichi Oga, Kei Itagaka, Yoshio Kawashita, Hironori Kobayashai,, Kenichiro Nishimura, Minoru